nNOS uncoupling has been implicated in several endothelium-dependent vascular disorders such as, in mesenteric artery of DOCA-salt hypertensive mice (Silva et al., 2016), thoracic aorta subjected to experimental atherosclerosis model (Capettini et al., 2011) and penile arteries of obese Zucker rat (Sánchez et al., 2012). The gene discussed is NOS1; the disease is atherosclerosis.