Other studies on BPH patients treated with finasteride further affirmed the pro-apoptotic effect of finasteride on the epithelial cells (Saez et al., 1998), and increased expression of the pro-apoptotic proteins (Caspases-3, -6, and -9) during finasteride treatment of BPH (Aline et al., 2005). This evidence concerns the gene CASP3 and benign prostatic hyperplasia.