Results showed that AR dose-dependently reduced the expression levels of phospho-Src (Tyr416) (Figure 3B) but not phospho-JAK2 (Y1007/1008) (data not shown) in both HCT-116 and SW480 cells, suggesting that AR inhibited Src-STAT3 signaling in CRC cells. This evidence concerns the gene STAT3 and colorectal carcinoma.