In AD patients, accumulation of both beta amyloid and tau (Morishima-Kawashima and Ihara, 2002; Leuba et al., 2009; Murphy and LeVine, 2010; Bloom, 2014), metabolic changes (Bracco et al., 2007; Lim et al., 2012), and decreased blood flows (Dukart et al., 2013; Long et al., 2013; Terada et al., 2013; Lin et al., 2014; Bailly et al., 2015) are observed in the ACC. The gene discussed is MAPT; the disease is Alzheimer disease.