Moreover, reduced CREB activity in NAc appears to have antidepressant-like effects in multiple stress models (Pliakas et al., 2001; Conti et al., 2002; Newton et al., 2002; Covington et al., 2011), suggesting that stress-induced CREB activation in NAc may contribute to the etiology of depression. Here, CREB1 is linked to depressive symptom measurement.