Patients with irritable bowel syndrome (IBS) who were treated with B. infantis 35624 reported that alleviation of symptoms such as abdominal pain and distention and presented a normalized ratio of the immunomodulatory cytokines IL-10/IL-12 (O'Mahony et al., 2005; Whorwell et al., 2006). This evidence concerns the gene IL10 and irritable bowel syndrome.