Notably, the p.I1307K missense mutation in APC (rs1801155), which has been previously shown to moderately increase colorectal cancer risk in the AJP (Woodage et al., 1998), was among the identified variants (MAF = 0·047), and was recommended for inclusion in AJP screening (Baskovich et al., 2016). Here, APC is linked to colorectal cancer.