These are: (1) the GLP-1 RA liraglutide given at a higher dose of 3 mg (a maximum dose of 1.8 mg is prescribed for diabetes treatment); (2) the 5-hydroxytryptamine2C (5-HT2C) serotonin receptor agonist lorcaserin; (3) combination treatment of the centrally acting sympathomimetic phentermine with topiramate; and (4) combined treatment with the μ-opioid antagonist naltrexone plus the noradrenaline (norepinephrine) and dopamine reuptake inhibitor bupropion. This evidence concerns the gene GLP1R and diabetes mellitus.