The mechanisms leading to weight gain with use of insulin (and probably also insulin secretagogues) in individuals with high blood glucose include a reduction in energy loss via glycosuria, the anabolic effects of insulin and an associated increase in food intake [15]; whilst the anabolic effects of insulin are beneficial in individuals who are relatively insulin deficient, in whom catabolic processes are highly active, for obese individuals this may be detrimental, contributing to a cycle of weight gain and worsening insulin resistance [16]. This evidence concerns the gene INS and Insulin resistance.