CTLA4 and neoplasm: Recently, the use of antibodies directed against different checkpoint targets, such as anti-PD-1 (Nivolumab, Pembrolizumab and Pidilizumab), anti-PD-L1 (MS-936559, MEDI4736, and MPDL3280A) and anti-CTLA4 (Ipilimumab) has been successfully implemented for the treatment of a number of different tumor entities [79].