Thus, by altering the phosphorylation status of STAT3, Dov targets the STAT3/LIN28/Let‐7/HMGA2 axis, which is emerging as an important oncogenic pathway for HMGA2 regulation in a subset of GB and breast cancer cells (Guo et al., 2013; Han et al., 2016; Mao et al., 2013). This evidence concerns the gene HMGA2 and breast carcinoma.