HMGA2 and cancer: Its three AT‐hook DNA binding domains interact with the minor groove at AT‐rich DNA sites and have intrinsic AP/dRP lyase activities that remove cytotoxic deoxyribosephosphate (dRP) sites to facilitate expedient base excision repair (BER) and protect HMGA2+ embryonic stem (ES) cells and cancer (stem) cells from genomic instability and apoptosis (Natarajan et al., 2013; Summer et al., 2009).