NFKB1 and familial pancreatic carcinoma: For example, LPS has been demonstrated to promote invasiveness of pancreatic cancer by activation of the TLR/MyD88/NF- NF-κB pathway53, to facilitate lung metastasis in a breast cancer via the prostaglandin E2-EP2 pathway54 and to increase liver metastasis of human CRC by stimulation of toll receptor TRL455.