More interestingly, we show that restoration of Alox5 expression can substantially increase the sensitivity of MLL-rearranged AML cells to standard chemotherapeutic agents such as DOX and Ara-C both in vitro and in vivo, as well as the underlying mechanism through suppressing the STAT and K-RAS oncogenic signaling pathways. This evidence concerns the gene ALOX5 and acute myeloid leukemia.