Another study showed that Alox5 deficiency inhibited in vitro colony-forming capacity of BM progenitor cells induced by some AML oncogenic fusion genes such as AML1-ETO9a, a potent oncogenic isoform of AML1-ETO resulting from t(8;21)44, but had no significant effects on AML1-ETO9a-induced leukemogenesis in vivo32. The gene discussed is ALOX5; the disease is acute myeloid leukemia.