In addition, stERAP-6 may provide long-lasting suppressive activity in ERα-negative breast cancer and endometrial cancer, because BIG3 and PHB2 are significantly overexpressed in some ERα-negative breast cancers9, and patients with endometrial cancer based on the RNAseq dataset from the Cancer Genome Atlas and Gene Expression Omnibus database (Supplementary Fig. S3j). The gene discussed is ESR1; the disease is endometrial cancer.