ZBTB48 and hereditary pheochromocytoma-paraganglioma: Furthermore, ZBTB48 localizes to chromosome 1p36, a region that is frequently rearranged (leiomyoma & leukaemia) or deleted (neuroblastoma, melanoma, Merkel cell carcinoma, pheochromocytoma, and carcinomas of colon and breast) in different human cancers and therefore might be a putative tumour suppressor 27, 28, 29, but not without dispute 30.