Likewise, ZBTB48's transcription factor activity could contribute to this as the transcriptional target VWA5A has been described as a tumour suppressor in breast cancer, nasopharyngeal carcinoma and melanoma 31, 32, 33 and MGAT5 and CCDC106 regulate PTEN and TP53, respectively 34, 35. This evidence concerns the gene TP53 and melanoma.