In addition to a reported competition for binding sites with TRF2 14 and other shelterin members, it will be interesting to see how ZBTB48 and the NR2C/F transcription factors relate to each other especially in ALT‐positive cancers in which variant repeat sequences such as TCAGGG are amplified and interspersed within the telomeric tract 21. Here, GRIN2C is linked to cancer.