Likewise, ZBTB48's transcription factor activity could contribute to this as the transcriptional target VWA5A has been described as a tumour suppressor in breast cancer, nasopharyngeal carcinoma and melanoma 31, 32, 33 and MGAT5 and CCDC106 regulate PTEN and TP53, respectively 34, 35. Here, PTEN is linked to breast cancer.