NFE2L2 and malignant colon neoplasm: Human chemoresistant colon cancer HT29/MDR cells and ER stress-resistant clones (HT29/Tg, HT29/Tun, HT29/Bfa) were grown in the absence or in the presence of PD98059 (10 μM, 72 h), which blocks Nrf2 nuclear translocation.