NFE2L2 and neoplasm: Since the expression of PERK and NRF2 is variably related to patient clinical outcome (Additional file 10), to better clarify the impact of PERK on tumor progression and response to therapy in a preclinical model, we implanted HT29/MDR cells transduced with inducible shRNA for PERK in NOD SCID BALB/c mice, treated with oxaliplatin, with or without doxycycline.