Nguyen et al. divided 220 patients with sepsis into 4 different groups according to Lac kinetics and showed an inverse correlation between IL-1 receptor antagonist, IL-6, IL-8, IL-10, TNF-α, intercellular adhesion molecule 1, high-mobility group box 1 protein, D-dimer, and caspase-3 concentrations and Lac clearance quartiles [22]. This evidence concerns the gene HMGB1 and Sepsis.