Much like variants in BCL11A, MYB and KLF-1 have been shown to be associated to Hb F levels in both HU-exposed and HU-naïve conditions [6, 12], in the present study, we have investigated the relationship between the four SAR1a promoter variants and baseline HbF in SCD patients from Cameroon, without any HU treatment. Here, MYB is linked to Schnyder corneal dystrophy.