Interestingly, the minor allele G of rs2296675 in MGMT had been previously shown to increase overall cancer risk of cancer across multiple tissues [per minor allele OR = 1.30, 95% CI 1.19,1.43, P = 4.1 × 10−8] [46], but risk of thyroid cancer was not specifically examined in the published CLUE II cohort study. This evidence concerns the gene MGMT and thyroid cancer.