However, TCF7L2-regulated intragenic enhancers included advanced stage markers in cancers such as Thyroid hormone signaling and Proteoglycan in cell adhesion [42, 43], whereas TCF7L2-regulated distal enhancers are enriched with the general signaling in cancer development such as PI3K-AKT pathway and Rap signaling [44]. The gene discussed is AKT1; the disease is cancer.