TCF7L2 and cancer: The Gene Enrichment and Pathway analyses further revealed that genes with TCF7L2-associated states are cancer type specific (Fig. 3a) and their intragenic enhancers are more associated with advanced stage markers in cancer such as Thyroid hormone signaling and Proteoglycan in cell adhesion (Fig. 3c), illustrating their functional relevance to specific cancer progression and metastasis.