Furthermore, we found that TXNIP−/− mice had a susceptibility to HFD, and the TXNIP−/− mice can be induced to NASH by HFD feeding alone, which is much more severe than HFD groups of WT mice and NLRP3−/− mice (Figure 3B, III vs I and II, arrow, hepatocyte ballooning). Here, NLRP3 is linked to metabolic dysfunction-associated steatohepatitis.