Although HFD groups of WT and NLRP3−/− mice showed similar grades of liver steatosis (Figure 3B, I and II), hepatocyte ballooning and inflammatory cell infiltration were markedly attenuated in the MCD-fed group of NLRP3−/− mice (Figure 3C, II vs I, arrows, hepatocyte ballooning and inflammatory cells, arrowhead, normal area). The gene discussed is NLRP3; the disease is fatty liver disease.