However, TXNIP deficiency can exacerbate mice NAFL induced by HFD alone and lead to NASH formation, which was probably caused by losing the TXNIP suppression effect on NLRP3 and then NLRP3 inflammasome activation in the KCs from TXNIP−/− mice. The gene discussed is TXNIP; the disease is metabolic dysfunction-associated steatohepatitis.