This hypertensive model was chosen for two reasons: 1) to mimic the low plasma renin state, albeit more exaggerated than the level observed, in African-ancestry individuals that has been suggested to reflect the elevated renin-angiotensin system activity at the tissue level in the kidney [45], and 2) maintenance of hypertension in the Ang II model requires activation of the immune system that is implicated in several identified loci.[46, 47] Kidney gene expressions of the identified genes were compared to age-matched untreated mice after two weeks of Ang II infusion, which increases SBP. Here, REN is linked to hypertensive disorder.