TCF21 is involved in epithelial differentiation and branching morphogenesis in kidney development,[48] and was associated with hypertension in a study of individuals of Japanese ancestry.[49] At the chromosome 7, rs115795127 is an intronic variant to FRMD3 (FERM domain containing 3) which encodes a protein involved in maintaining cell shape and integrity. Here, TCF21 is linked to hypertensive disorder.