When combining summary statistics for SBP, DBP, and HTN using the multi-trait approach CPASSOC,[39] we identified one locus by the multi-trait statistic SHom (EVX1/HOXA) and six loci by SHet (ULK4, TCF21, EVX1/HOXA, IGFBP3, CDH17, ZNF746) at P < 5×10−8 (S2E and S2F Fig). This evidence concerns the gene IGFBP3 and hypertensive disorder.