IGFBP3 and hypertensive disorder: Four loci (ULK4, PLEKHG1, EVX1/HOXA cluster, and GPR20) have been reported in our previous BP GWAS of African ancestry (S3 Fig),[7, 18] and two loci (IGFBP3, CDH17) have been reported in multiple-trait analyses of African-ancestry studies (Fig 2D–2F).[39] A composite genetic-risk score using the eleven variants identified accounted for 1.89%, 2.92%, 1.03% and 1.08% of the variance for SBP, DBP, PP and HTN respectively.