Notably, HuAd5-KH demonstrated therapeutic benefit after a single vaccination in an experimental model of chronic L. donovani infection [12] and HuAd5-A2 (expressing the Leishmania A2 antigen) was shown to have prophylactic benefit in a primate model of infection, albeit requiring a recombinant A2 protein / rIL-12 boost [28]. The gene discussed is RPRD1B; the disease is infection.