The Kaplan-Meier curves with a log-rank test indicated that patients with positive MYSM1 expression seemed to be remarkably correlated with poor overall survival than those CRC patients with negative MYSM1 expression (P<0.001, Fig 4).Thisresultsuggestedthat the MYSM1 expression in tumor cells was an promising adverse predictive factor for overall survival of CRC patients.Furthermore, we determined that the expression of MYSM1 in tumor cells wasan independent predictorof OS according to the multivariate Coxmodel analysis (Table 2). Here, MYSM1 is linked to neoplasm.