In this study, we detected MYSM1expression in tumor specimens resected from 123 CRC patients by immunochemistry and Western blot analysis.Theresults showed MYSM1was significantly highly expressed in primary carcinoma tissues compared with normal mucosa tissues, and MYSM1was significantly increased in liver metastasis tissues compared with primary carcinoma tissues, suggesting that high MYSM1 expression was positively correlated with CRC tumorigenesis and development. This evidence concerns the gene MYSM1 and carcinoma.