Despite the fact that a wide range of inflammatory cytokines has been associated with pre-malignant chronic inflammation of the colon and inflammatory bowel disease [23], gaps exist in our understanding of the regulatory mechanisms (beyond plasma membrane association or phosphorylation of components of the NOX1 complex) [24, 25] that control NOX1 expression in the colon, particularly in response to inflammatory stimuli. Here, NOX1 is linked to inflammation.