Thus, demonstration of enhanced BrdU incorporation in HT-29 and WiDr colon cancer cells following IL-4 exposure or transient transfection of NOX1-L, respectively, is consistent with ROS-related regulation of cyclin D3 levels in our colon cancer lines, and is in harmony with a previous study of the effect of NOX1 levels on cyclin D1 expression in murine lung epithelial cells [60]. Here, CCND3 is linked to malignant colon neoplasm.