We recently reported that stable knockdown of NOX1 in HT-29 colon cancer cells (clone 6A with > 90% inhibition of NOX1; and clone Si6/G6 with ≈ 65% NOX1 knockdown) significantly decreases ROS formation compared to cells carrying a scrambled NOX1 shRNA (SC cells) or the parental line [16]. The gene discussed is NOX1; the disease is malignant colon neoplasm.