TSC2 and angiomyolipoma: To determine the effects of lysosomal inhibition on the transcriptome of mTORC1-hyperactive cells, we treated TSC2-deficient human kidney-derived angiomyolipoma cells (621-101), TSC2-empty vector angiomyolipoma cells (621-102), and TSC2-add back angiomyolipoma cells (621-103) with 5μM of CQ for 24 hours.