Moreover, differentiated expression of PKM2 and GLS1 in CRC cell lines can increase oxaliplatin-resistance by raising Pgp expression and inhibiting cell apoptosis, whereas in drug-resistance CRC cell lines, the knockdown of PKM2/GLS1 expression can restore oxaliplatin-sensitivity by degrading Pgp expression and inducing cell apoptosis. This evidence concerns the gene GLS and colorectal carcinoma.