CD74 and neoplasm: There was an additive increase of the MHC II pathway protein and gene expression with the combination of entinostat and azacytidine treatment, specifically MHC II complex genes CIITA and CD74. This study demonstrates that the combination of entinostat plus azacytidine upregulates MHC II mRNA and protein expression in OVCA cells in vitro and tumors in vivo, and reduce primary tumor growth.