S100A7A and adenocarcinoma: Furthermore, DNA methylation levels over -412 CpG sites were significantly decreased in adenocarcinoma patients with a high percentage (>55%) of S100A15 nuclear stain positive cells as compared with that in those with a low percentage of S100A15 nuclear stain positive cells (80.7±15.8 vs. 90.9±10.8, p=0.043).