In the 115 lung adenocarcinoma cases, total score (4.77±1.1 versus 3.75±1.48, adjusted p=0.002, 95%CI 0.126-0.538), intensity score (1.56±0.56 versus 1.29±0.55, adjusted p=0.025, 95%CI 0.015-0.209), and percentage score (3.18±0.8 versus 2.46±1.14, adjusted p<0.001, 95%CI 2.42-7.876) of S100A15 nuclear stain were all significantly increased in patients with advanced stage tumor (stage IIIB and IV, n = 91) compared with that in those with early stage tumor (stage I - IIIA, n = 24, Figure 1A-C). Here, S100A7A is linked to lung adenocarcinoma.