In our previous whole-genome gene expression study, we found that nuclear accumulation of S100A15 were increased in advanced stage NSCLC patients [1], but the potential of S100A15 as a determinant of treatment outcomes, and the underlying mechanisms by which S100A15 would be involved in proliferation, migration, and invasion of lung cancer have not yet been understood [1, 7]. This evidence concerns the gene S100A7A and lung cancer.