To investigate the role of S100A15 gene promoter DNA methylation in the development of distant metastasis in lung AC patients, DNA methylation levels were measured by pyrosequencing in DNA samples extracted from the FFPE tissues of 37 adenocarcinoma patients with distant metastasis (M1), and 14 adenocarcinoma patients without distant metastasis (M0). This evidence concerns the gene S100A7A and adenocarcinoma.