We retrospectively examined S100A15 protein expression, as determined by immunohistochemistry (IHC) stain, in a cohort of 178 subjects with NSCLC diagnosed through bronchoscopy-guided biopsy, and correlated it with their clinical characteristics, including tumor stage (TNM staging), treatment response, and overall survival (1- and 3-year). This evidence concerns the gene S100A7A and non-small cell lung carcinoma.