Bioinformatic analysis of genes of interest against TCGA RNA sequencing data proposed TRIM28, VIM, NAP1L1 and DPYSL2 as promising “glioma versus reference” biomarkers, and suggested CRMP1, NAP1L1, NUCL, ACTB and VIM for discrimination between GBM and LGG. This evidence concerns the gene TRIM28 and central nervous system cancer.