Different concentrations of adiponectin (5 μg/mL for the high concentration group, 3.5 μg/mL for the medium concentration group, and 1 μg/mL for the low concentration group) were administered to KFs and NFs along with CTGF (6 ng/mL) for 24 h (Figure 3B) to explore the effect of adiponectin on keloid development and investigate whether adiponectin regulated CTGF-induced KFs proliferation. This evidence concerns the gene CCN2 and keloid.