Based on these intriguing observations, we compared the expression levels of adiponectin and its receptors in patients with keloids and normal subjects, and further aimed to explore whether adiponectin would influence the CTGF-induced proliferation, migration and deposition of ECM in KFs and normal dermal fibroblasts (NFs) cultured in vitro to investigate the association between adiponectin and CTGF in keloids and to obtain a better understanding of the role of adiponectin in keloid pathogenesis. Here, CCN2 is linked to keloid.