Additionally, we observed increases in the expression of EIF2AK2 (24-fold), OAS1 (10-fold), IFNA4 (10-fold) and IFNB1 (10-fold) in the lungs of rWSN-GH-NS1-Y84F infected mice treated with IFN-β on day 1 post-infection compared with the lungs of infected, but untreated mice (Figure 11B). The gene discussed is IFNA4; the disease is infection.