This study investigatedthe association of three single nucleotide polymorphisms (SNPs) in theBCHE gene: -116G > A (rs1126680), 1615GA (rs1803274), 1914A< G (rs3495), with obesity and lipid metabolism markers, body mass index (BMI),total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high densitylipoprotein cholesterol (HDL-C), triglyceride (TG) levels, and BChE enzymaticactivity in obese (BMI≥30/n = 226) and non-obese women (BMI < 25/n = 81).BCHE SNPs genotyping was obtained by TaqMan allelicdiscrimination assay and by RFLP-PCR. Here, BCHE is linked to obesity due to melanocortin 4 receptor deficiency.