To select our target loci, we first profiled genome-wide mRNA expression by RNA-seq, and surveyed genome-wide histone acetylation by performing chromatin immunoprecipitation followed by high-throughput DNA sequencing (ChIP-seq) for H3K27ac, a chromatin mark that is associated with active transcription18 and HDAC3 (ref. 19), in the murine neuroblastoma cell line, Neuro-2a (N2a). This evidence concerns the gene HDAC3 and neuroblastoma.