Our observations in the mouse model being in apparent discrepancy with these conclusions, we re-investigated the respective functions of BRAF and CRAF by using RNA interference experiments in three human melanoma cell lines harbouring NRAS mutations: WM1361 (NRASQ61K), WM852 (NRASQ61R) and Sbcl2 (NRASQ61K). This evidence concerns the gene BRAF and melanoma.