To address this question, we re-evaluated the respective contribution of RAF kinases in RAS-induced melanoma using NRASQ61K-induced mouse melanoma models in which single or compound ablation of Braf and Craf genes can be achieved in the melanocyte lineage upon tyrosinase promoter-driven Cre or CreERT2 expression21, 28, 29. The gene discussed is RAF1; the disease is melanoma.