Furthermore, genomic analysis in DAXX-knockdown/PTEN-deficient GBM samples display a genome-wide H3.3 distribution change (1,751 genes with H3.3 different binding signal) and upregulation of several tumour suppressor genes and downregulation of various oncogenes (1,403 genes with differential expression), including CCND1, MYC, FOS, SOX2 and OLIG2, compared with shControl/PTEN-deficient GBM samples. This evidence concerns the gene SOX2 and glioblastoma.