MYC and neoplasm: Gene set enrichment analysis showed that the three most overrepresented gene sets that positively correlated with DAXX expression in GBM patients were E2F targets, G2M checkpoint components and MYC targets (Fig. 6f,g); in concordance with our data showing that DAXX knockdown affects cell cycle progression, cellular proliferation (Supplementary Figs 4 and 5) and tumour growth (Fig. 5 and Supplementary Fig. 16).