Moreover, survival analysis showed mice intracranially engrafted with DAXX-kd/PTEN-deficient GBM cells (Fig. 5d, Supplementary Fig. 16f) survived significantly (P<0.0001) longer than animals implanted with DAXX-kd/PTEN-WT GBM spheres (Fig. 5f and Supplementary Fig. 16f). The gene discussed is PTEN; the disease is glioblastoma.