In a therapeutic context, DAXX–H3.3 interaction can be disrupted in PTEN-null cells using staple peptides as reported by Kim and collegues61 for the disassociation of an EZH2-EDD complex in a leukaemia model; or by using small molecules which have been efficient at antagonizing chromatin associated proteins and their interactions with other proteins62. Here, PTEN is linked to leukemia.