PTEN and glioblastoma: We suggest that downregulation of expression of these GBM-TFs can be associated with the PTEN–DAXX–H3.3 complex, since H3.3 is enriched near the transcription binding sites of these genes, as we observed from the genomic data and in concordance with the literature12, and DAXX disruption only affects their expression in PTEN-deficient cells.