CD4 and AIDS: In the context of NK cells working against viral nucleic acid invasion of the host DNA, the function of NK cells in patient immunity to HIV, and the stem cell properties of memory CD4 T cells, it is imperative that investigators harness expertise in virology, immunology, and molecular biology to make cross-field efforts to connect the dots and delineate the circuits that maneuver a sophisticated, protective epigenetic network toward an HIV-AIDS cure.