ANXA3 and prostate intraepithelial neoplasia: However, ANXA3 expression in prostate cancer tissue was significantly lower than that in benign prostate cancer tissue and high-grade prostatic intraepithelial neoplasia; an incomplete expression of ANXA3 protein was found in about 27.2% of patients, indicating that downregulated ANXA3 could promote occurrence and development of prostate cancer [11].