IL2 and neoplasm: To gain greater insights into the role of mTORC1 inhibition in T-cell effectors in determining Gzm-B-mediated T-cell fates in vivo, we further designed an experiment in tumor-bearing mice, and tested Gzm-B susceptibility of adoptive IL-2 effectors (with or without mTORC1 inhibition) within tumors with enriched immunosuppressive Treg cells.