APP and infection: Simulations of this variability in PK-PD have been used to evaluate marbofloxacin in the treatment of APP infections in nursery and fattening pigs, and showed that a single dose of 8 mg/kg would provide robust efficacy and minimise resistance development in APP with MICs of 0.03–0.12 μg/mL [9, 10] which are comparable to the APP MIC range reported here.