In conclusion, this study provides evidence that some food groups modulate the effect of APOA1 and APOC3 SNPs in relation to MetS risk; being A and T allele carriers of APOA1 (rs670, rs5069) and C allele carriers of APOC3 (rs5128) further increased MetS risk in individuals with higher consumption of sweet beverages and fish groups. The gene discussed is APOC3; the disease is metabolic syndrome.