Therefore, it can be claimed that a possible mechanism of norzoanthamine hydrochloride action may be through inhibition of collagenase I. The development of synthetic and natural MMP-1 inhibitors such as the ligand 1-enol, promises for not only novel therapeutic measures for the prevention and treatment of osteoporosis, but it will also provide potential therapeutics for the modulation of extracellular matrix remodeling, and the disturbances of the microenvironment involved in the pathogenesis and disease progression of some cancers and autoimmune diseases. This evidence concerns the gene MMP1 and autoimmune disease.