PLCG2 and autoinflammation-PLCG2-associated antibody deficiency-immune dysregulation: One such disease is autoinflammation and PLCγ2-associated antibody deficiency and immune dysregulation (APLAID), caused by missense mutations in (the gene) PLCG2. This condition has clinical manifestations of inflammation (recurrent skin blistering, pneumonitis, and ocular inflammation) in combination with susceptibility to infections (recurrent sino-pulmonary infections) due to low concentrations of IgA and IgM (15).