Tammana et al. (15) redirected umbilical cord blood T cells to eliminate, in vitro and in vivo, both lymphoma and leukemia cells by transducing T cells with CD19ζ CAR construct containing CD28 (CD19-28ζ) or 4-1BB (CD19-BBζ) or a combination of both (CD19-28BBζ) co-stimulatory molecules fused with ζ chain in the intracellular domain. Here, CD28 is linked to lymphoma.