Indeed, compared to the first generation of CAR T cells, (i) CD28-CAR T cells secrete higher levels of interferon gamma (IFNγ); (ii) efficiently eradicate transforming growth factor beta (TGFβ) producing tumor cells; and (iii) suppress TGFβ inhibition of T cell expansion (12, 13). The gene discussed is IFNG; the disease is neoplasm.