IL6 and Mental deterioration: A cohort study that included 5,217 cases and followed up for 10 years found that high IL-6 levels in middle age will increase the risk of cognitive decline by as high as 1.81 times (Singh-Manoux et al., 2014), and this was further demonstrated by another study that the negative effects of high IL-6 on cognition will not change concerning use or non-use of statins (Wichmann et al., 2014).