The relationship between depression/anxiety and cardiovascular diseases involves an alteration of numerous biological systems, pathways, and molecules, such as the autonomic nervous system, platelet receptors, coagulopathic factors (i.e. plasminogen activator inhibitor-1 or fibrinogen), pro-inflammatory cytokins, endothelial function, and neurohormonal factors [20]. Here, SERPINE1 is linked to cardiovascular disorder.