By univariate analysis, the following parameters were considered for EFS and OS determination: tumor burden (<vs≥3.0 cm), tumor progression (low vs high), lymph node status (<3 vs≥3 or 4+) and median values of serum Shh (<vs≥36.42 pg/mL) and IL-6 (<vs≥167.90 pg/mL). Here, SHH is linked to neoplasm.