CHRNA7 and ocular hypertension: The α7-nAChR mRNA level in EVC-treated eyes relative to control eyes (Fig. 1B) decreased to 95% ± 8% (mean ± SE) on day 1 (n = 4), to 73% ± 4% on day 3 (n = 4, p = 0.008), to 41% ± 10% on day 5 (n = 4, p = 0.010) and to 32% ± 2% on day 7 (n = 6, p = 0.001), confirming that ocular hypertension causes a gradual, time-dependent decrease in retinal α7-nAChR mRNA expression (Fig. 1B).