Del(17p13) results in the concomitant loss of TP53 and MIR3676, with the former being essential for the DNA damage response, and the latter in inhibiting the CLL oncogene, TCL1A. In del(11q), the deleted region involves ATM, a DNA repair gene, and frequently BIRC3, a gene important for the regulation of non-canonical NFKB signaling. This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.