Here, we proposed that the seven lncRNAs in our top list, including lnc-C1orf222-1, HAGLROS, lnc-IGFBP7-3, lnc-FSCN1-2, DDX11-AS1, lnc-COPZ2-1 and lnc-IL17RC-2, played important roles in the liver hepatocellular carcinoma, whose dysregulated expression levels led to cancer progression. The gene discussed is DDX11; the disease is cancer.