In addition, Shah et al,15 using osteoblasts derived from age-matched and paired humeral head samples with osteoarthritis and osteoporosis, showed that cortical and subchondral bone had greater proangiogenic (higher levels of vascular endothelial growth factor A messenger RNA and protein release) capacity and fracture healing characteristics compared with trabecular bone. The gene discussed is VEGFA; the disease is osteoporosis.